Endocrine Abstracts

Introduction: Modern research studies reveal a negative impact of diabetes on cognitive function. Nonetheless, little is known about the risk factors that are involved in this disturbance. The present study aimed to examine the associations among cognitive/emotional functions and a number of metabolic factors associated with diabetes, in order to identify a possible link between cognitive decline and diabetes.Materials and methods: One hundred thirty fiv...

Several studies have pointed to a neural regulation of glucose dependent insulinotropic peptide (GIP) secretion. Bombesin is a neuropeptide found in the amphibian brain and gastrointestinal system – homologous to the C terminus of gastrin-releasing protein (GRP) in mammalians, which displays a wide range of metabolic actions.Aim: Aim of this study was to investigate the effect of intracerebroventicular infusion of bombesin in a centrally mediated re...

Objective: Parathyroidectomy (PTx) improves quality of life (QoL) in patients with primary hyperparathyroidism (PHPT). Whether this effect is modified according to the patients’ age is unknown. The aim of this study was to evaluate the impact of age on the effect of PTx on QoL and frailty in patients with PHPT, six months post-PTx. Methods: This was a prospective cohort study, including patients with PHPT, admitted from January 2016 to December 2019...

Background: Sulfonylureas (SUs) are known to increase fasting insulin levels in patients with Type 2 Diabetes (T2D) treated with these agents. Whether this increase is related to a greater risk of hypoglycemia has not yet been sufficiently elucidated.Methods: The study included 58 patients with T2D who had been on treatment with SUs, but not insulin, for more than 2 years. Confirmed hypoglycemic episodes during the past year were self-reported by the pat...

Introduction: The present study aimed to investigate whether women who developed gestational diabetes mellitus (GDM) comply with the guidelines for gestational weight gain (GWG) according to their pre-pregnancy Body Mass Index (BMI).Methods: A retrospective study was conducted involving 195 pregnant women with GDM, aged 25–45 years, attending an academic hospital outpatient clinic. These women were divided into three groups according to pre-pregnanc...

Introduction: Gestational Diabetes Mellitus (GDM) is a disorder of glucose tolerance which is diagnosed for the first time during pregnancy. Thyroid disease is common in women of reproductive age and during gestation; both diseases have an adverse impact on pregnancy outcomes. The aim of this study was to assess the clinical and ultrasonographic characteristics in women with co-existing GDM and thyroid disease.Material and methods: In total, 112 pregnant...

Objective: To report a case of a patient diagnosed with latent autoimmune diabetes of adulthood (LADA) based on clinical presentation and positive glutamic acid decarboxylase antibodies (GAD-abs) that converted to antibody negative diabetes after combined treatment with sitagliptin and vitamin D.Methods: A 31-year-old male presented at the emergency room with symptoms of polyuria, polydipsia, and weight loss. Blood glucose was 300 mg/dl with mild ketonur...

Objective: To report the unusual presentation of a thyrotropinoma in a patient with: i) accelerated bone turnover, evident as osteopenia and increased serum alkaline phosphatase level, and ii) a pericardial effusion, years before diagnosis, that resolved completely following surgery and somatostatin analogue treatment.Case report: A 38-year-old man had been treated for years for presumed hypothyroidism with thyroxine supplementation based on elevated TSH...

Background and aims: Exercise intervention programs have been proved beneficial for inactive type 2 diabetes patients by improving physical fitness, anthropometric parameters, glycaemic control and lipid profile. The aim of this study was to examine the additional benefits of a supervised systematic exercise program in physically active postmenopausal women with type 2 diabetes.Materials and methods: Ten physically active, postmenopausal women with type ...

Introduction: The results of this epidemiological study demonstrate the burden of 25-hydroxyvitamin D deficiency in two sunny Mediterranean countries Greece and Cyprus- and some of the related risk factors. These two populations were examined together due to their common phylogenetic origin. Up until now there are no available data for the mean Vitamin D levels of the Cypriot adult population. An early identification of vitamin D deficiency is now considered as the cornerstone...